NDLI: Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.

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Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.

Content Provider	Europe PMC
Author	Rojczyk, Philine Seitz-Holland, Johanna Kaufmann, Elisabeth Sydnor, Valerie J. Kim, Cara L. Umminger, Lisa F. Wiegand, Tim L. T. Guenette, Jeffrey P. Zhang, Fan Rathi, Yogesh Bouix, Sylvain Pasternak, Ofer Fortier, Catherine B. Salat, David Hinds, Sidney R. Heinen, Florian O’Donnell, Lauren J. Milberg, William P. McGlinchey, Regina E. Shenton, Martha E. Koerte, Inga K.
Editor	Brand, Serge
Copyright Year	2023
Abstract	Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a compounding effect on WM remains largely unknown. We evaluated sleep and diffusion magnetic resonance imaging (dMRI) data from 180 male post-9/11 veterans diagnosed with (1) PTSD (n = 38), (2) mTBI (n = 25), (3) comorbid PTSD+mTBI (n = 94), and (4) a control group with neither PTSD nor mTBI (n = 23). We compared sleep quality (Pittsburgh Sleep Quality Index, PSQI) between groups using ANCOVAs and calculated regression and mediation models to assess associations between PTSD, mTBI, sleep quality, and WM. Veterans with PTSD and comorbid PTSD+mTBI reported poorer sleep quality than those with mTBI or no history of PTSD or mTBI (p = 0.012 to <0.001). Poor sleep quality was associated with abnormal WM microstructure in veterans with comorbid PTSD+mTBI (p < 0.001). Most importantly, poor sleep quality fully mediated the association between greater PTSD symptom severity and impaired WM microstructure (p < 0.001). Our findings highlight the significant impact of sleep disturbances on brain health in veterans with PTSD+mTBI, calling for sleep-targeted interventions.
Journal	Journal of Clinical Medicine [J Clin Med]
Volume Number	12
DOI	10.3390/jcm12052079
PubMed Central reference number	PMC10004675
Issue Number	5
PubMed reference number	36902865
e-ISSN	20770383
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-03-06
Access Restriction	Open
Subject Keyword	sleep disturbances mTBI PTSD dMRI PSQI military
Content Type	Text
Resource Type	Article
Subject	Medicine

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