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| Content Provider | EDP Sciences |
|---|---|
| Author | Sylvie Bonin-Guillaume Gaëlle Martin Joseline Zafack Gaétan Gentile Véronique Allaria-Lapierre Vincent Sciortino Xavier Thirion Joëlle Micallef |
| Abstract | Objectifs. Notre étude identifie et caractérise les patients atteints de la maladie d’Alzheimer et maladies apparentées (MAMA) en décrivant leur exposition aux antipsychotiques et aux autres médicaments psychotropes. Méthodes. Cette étude a été réalisée en 2010 à partir de la cohorte Paca-Alz constituée de patients atteints de MAMA, bénéficiant d’une affection de longue durée (ALD) 15 et/ou ayant eu au moins une délivrance de traitement spécifique anti-Alzheimer et affiliés au régime général de l’Assurance maladie de la région Provence-Alpes-Côte d’Azur (PACA)-Corse. Les psychotropes ont été identifiés par leur code anatomique thérapeutique et chimique (ATC). Une consommation chronique d’antipsychotiques a été définie par plus de 3 remboursements consécutifs. Résultats. En 2010, parmi les 34 696 patients inclus, 26,9 % étaient des hommes et 69 % avaient 80 ans et plus. Parmi eux, 26 % ont reçu ≥1 antipsychotique avec 61,3 % de consommation chronique. Cette exposition est en 3e position après les antidépresseurs (47 %) et les anxiolytiques (45,3 %). L’antipsychotique le plus utilisé était la rispéridone (11,2 %). Le recours aux soins (hospitalisations, infirmiers, consultations médicales) était significativement plus important chez les patients sous antipsychotiques. Conclusion. La consommation d’antipsychotiques chez les patients déments reste importante. Le suivi de cette cohorte permettra d’identifier si les pratiques de prescription et de prise en charge s’améliorent avec les successives recommandations. |
| Ending Page | 222 |
| Starting Page | 213 |
| Page Count | 10 |
| File Format | HTM / HTML PDF |
| ISSN | 00405957 |
| Alternate Webpage(s) | https://www.journal-therapie.org/articles/therapie/abs/2014/03/th142118/th142118.html |
| e-ISSN | 19585578 |
| Issue Number | 3 |
| Journal | Thérapie |
| Volume Number | 69 |
| DOI | 10.2515/therapie/2014015 |
| Language | French |
| Publisher | EDP Sciences |
| Publisher Date | 2014-05-01 |
| Access Restriction | Subscribed |
| Rights Holder | © 2014 Société Française de Pharmacologie et de Thérapeutique |
| Subject Keyword | pharmaco-épidémiologie maladie d’Alzheimer traitement anti-démence antipsychotiques psychotropes pharmacoepidemiology / Alzheimer’s disease / antipsychotics / anti-dementia drugs / antipsychotics / psychotropic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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