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| Content Provider | EDP Sciences |
|---|---|
| Author | Emilie Warrick Valérie Bergoglio Françoise Bernerd Thierry Magnaldo |
| Abstract | La plupart des pathologies génétiques récessives à expression cutanée, les génodermatoses, restent, à ce jour, sans traitement. Le transfert, dans les cellules en culture du patient, de l'allèle sain du gène dont l'altération est responsable de la maladie puis la réimplantation chez le patient des cellules génétiquement corrigées pourraient constituer un traitement alternatif. La pérennité de la correction génétique des greffons chez le patient s'appuie nécessairement sur la correction des cellules souches épidermiques. Ainsi, la première greffe de cellules souches génétiquement corrigées ex vivo a été rapportée très récemment chez un patient atteint d'épidermolyse bulleuse jonctionnelle. En complément de ce succès, nous décrivons ici une nouvelle méthode de sélection non invasive et non immunogène des cellules souches épidermiques génétiquement manipulées. Cette stratégie pourrait être applicable à la thérapie génique cutanée ex vivo des génodermatoses associées à une prédisposition au cancer, comme notamment le xeroderma pigmentosum. |
| Ending Page | 41 |
| Starting Page | 33 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 12950661 |
| Alternate Webpage(s) | https://www.biologie-journal.org/articles/jbio/abs/2008/01/jbio2008005/jbio2008005.html |
| e-ISSN | 17606128 |
| Issue Number | 1 |
| Journal | Journal de la Société de Biologie |
| Volume Number | 202 |
| DOI | 10.1051/jbio:2008005 |
| Language | French |
| Publisher | EDP Sciences |
| Publisher Date | 2008-01-01 |
| Access Restriction | Subscribed |
| Rights Holder | © Société de Biologie, 2008 |
| Subject Keyword | peau cellules souche thérapie génique xeroderma pigmentosum |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Aging |
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