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MKP5 deficiency protects against pressure overload-induced cardiac hypertrophy and fibrosis (Dataset)
| Content Provider | Dryad |
|---|---|
| Author | Zhang, Xiaoying Yu, Jun Zhong, Chao Zhao, Zhiqiang Roy, Rajika Baldini, Margaret |
| Abstract | Cardiac pressure overload resulting from transaortic constriction (TAC) induces MKP-5 expression and facilitates cardiac hypertrophy and fibrosis. In this dataset, we show that MKP-5 deficiency attenuates cardiac fibrosis after TAC. In vitro, bone marrow-derived macrophages (BMDMs) from MKP-5 knockout mice exhibit enhanced phosphorylation of p38 MAPK, JNK, and Erk compared to BMDMs from wild-type mice in response to IL-4 stimulation. |
| File Size | 33696029 |
| File Format | HTM / HTML |
| ISSN | 16643224 |
| DOI | 10.5061/dryad.vdncjsz2v |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973256 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973257 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973265 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973258 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973259 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973254 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973253 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973250 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973249 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973251 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973252 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973260 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973261 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973262 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973263 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973255 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/2973287 |
| Language | English |
| Publisher Date | 2024-03-04 |
| Access Restriction | Open |
| Subject Keyword | Fibrosis Hypertrophy Macrophages |
| Content Type | Text |
| Resource Type | Data Set |
| Subject | Immunology and Allergy Immunology |
