Loading...
Please wait, while we are loading the content...
Similar Documents
Data from: Integrating influenza antigenic dynamics with molecular evolution (Dataset)
| Content Provider | Dryad |
|---|---|
| Author | Bedford, Trevor Suchard, Marc A. Lemey, Philippe Dudas, Gytis Gregory, Victoria Hay, Alan J. McCauley, John W. Russell, Colin A. Smith, Derek J. Rambaut, Andrew |
| Abstract | Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay. Here, we extend previous approaches to antigenic cartography, and simultaneously characterize antigenic and genetic evolution by modeling the diffusion of antigenic phenotype over a shared virus phylogeny. Using HI data from influenza lineages A/H3N2, A/H1N1, B/Victoria and B/Yamagata, we determine patterns of antigenic drift across viral lineages, showing that A/H3N2 evolves faster and in a more punctuated fashion than other influenza lineages. We also show that year-to-year antigenic drift appears to drive incidence patterns within each influenza lineage. This work makes possible substantial future advances in investigating the dynamics of influenza and other antigenically-variable pathogens by providing a model that intimately combines molecular and antigenic evolution. |
| File Size | 1770372 |
| File Format | HTM / HTML |
| ISSN | 2050084X |
| DOI | 10.5061/dryad.rc515 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16202 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16206 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16203 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16207 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16210 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16204 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16208 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16205 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/16209 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85148 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85152 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85149 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85153 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85156 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85150 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85154 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85151 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/85155 |
| Language | English |
| Publisher Date | 2014-02-05 |
| Access Restriction | Open |
| Subject Keyword | Influenza A/h3n2 Bayesian Multidimensional Scaling Hemagglutination Inhibition (hi) Titers Influenza A/h1n1 Antigenic Drift Influenza Virus Influenza B/victoria Nucleotide Sequence Accessions Adaptive Evolution Influenza B/yamagata |
| Content Type | Text |
| Resource Type | Data Set |
| Subject | Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |
