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Data from: SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals (Dataset)
| Content Provider | Dryad |
|---|---|
| Author | Prete Jr, Carlos A. Buss, Lewis F. Whittaker, Charles Salomon, Tassila Oikawa, Marcio K. Pereira, Rafael H. M. Moura, Isabel C. G. Delerino, Lucas Barral-Netto, Manoel Tavares, Natalia M. França, Rafael F. O. Boaventura, Viviane S. Miyajima, Fabio Mendrone-Junior, Alfredo de Almeida Neto, César Salles, Nanci A. Ferreira, Suzete C. Fladzinski, Karine A. de Souza, Luana M. Schier, Luciane K. Inoue, Patricia M. Xabregas, Lilyane A. Crispim, Myuki A. E. Fraiji, Nelson Araujo, Fernando L. V. Carlos, Luciana M. B. Pessoa, Veridiana Ribeiro, Maisa A. de Souza, Rosenvaldo E. Cavalcante, Anna F. Valença, Maria I. B. da Silva, Maria V. Lopes, Esther Amorim Filho, Luiz Mateos, Sheila O. G. Nunes, Gabrielle T. da Silva, Sônia M. N. Silva-Junior, Alexander L. Busch, Michael P. Castro, Marcia C. Dye, Christopher Ratmann, Oliver Faria, Nuno R. Nascimento, Vítor H. Sabino, Ester C. |
| Abstract | The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Here we tested monthly blood donation samples for IgG antibodies from March 2020 to March 2021 in eight of Brazil’s most populous cities. The inferred attack rate of SARS-CoV-2 adjusted for seroreversion in December 2020, before the Gamma VOC was dominant, ranged from 19.3% (95% CrI 17.5% - 21.2%) in Curitiba to 75.0% (95% CrI 70.8% - 80.3%) in Manaus. Seroprevalence was consistently smaller in women and donors older than 55 years. The age-specific infection fatality rate (IFR) differed between cities and consistently increased with age. The infection hospitalisation rate (IHR) increased significantly during the Gamma-dominated second wave in Manaus, suggesting increased morbidity of the Gamma VOC compared to previous variants circulating in Manaus. The higher disease penetrance associated with the health system’s collapse increased the overall IFR by a minimum factor of 2.91 (95% CrI 2.43 – 3.53). These results highlight the utility of blood donor serosurveillance to track epidemic maturity and demonstrate demographic and spatial heterogeneity in SARS-CoV-2 spread. |
| File Size | 20468171 |
| File Format | HTM / HTML |
| ISSN | 2050084X |
| DOI | 10.5061/dryad.dz08kps08 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429258 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429255 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429257 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429269 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429253 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/1429274 |
| Language | English |
| Publisher Date | 2022-04-07 |
| Access Restriction | Open |
| Subject Keyword | Sars-cov-2 Attack Rate Herd Immunity Reinfection Seroprevalence Blood Donors Infection Fatality Rate |
| Content Type | Text |
| Resource Type | Data Set |
| Subject | Neuroscience Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |
