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Data from: Ancient recombination events between human herpes simplex viruses (Dataset)
| Content Provider | Dryad |
|---|---|
| Author | Burrel, Sonia Boutolleau, David Ryu, Diane Agut, Henri Merkel, Kevin Leendertz, Fabian H. Calvignac-Spencer, Sébastien |
| Abstract | Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to date contain HSV-1 fragments. Using phylogenomic analyses, we could also show that two main HSV-2 lineages exist. One lineage is mostly restricted to subSaharan Africa whereas the other has reached a global distribution. Interestingly, only the worldwide lineage is characterized by ancient recombination events with HSV-1. Our findings highlight the complexity of HSV-2 evolution, a virus of putative zoonotic origin which later recombined with its human-adapted relative. They also suggest that coinfections with HSV-1 and 2 may have genomic and potentially functional consequences and should therefore be monitored more closely. |
| File Size | 14446793 |
| File Format | HTM / HTML |
| ISSN | 07374038 |
| DOI | 10.5061/dryad.9t21c |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/72956 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/72955 |
| Language | English |
| Publisher Date | 2018-02-27 |
| Access Restriction | Open |
| Subject Keyword | Recombination Human Herpesvirus 2 Herpes Simplex Virus 1 Human Herpesvirus 1 Herpes Simplex Virus 2 Holocene |
| Content Type | Text |
| Resource Type | Data Set |
| Subject | Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics |
