NDLI: Data from: An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations (Dataset)

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Data from: An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations (Dataset)

Content Provider	Dryad
Author	Ingham-Dempster, Timothy Walker, Dawn C. Corfe, Bernard M. Ingham-Dempster, Tim
Abstract	Colorectal cancer (CRC) is a major cause of cancer mortality. Colon crypts are multi-cellular flask-shaped invaginations of the colonic epithelium, with stem cells at their base which support the continual turnover of the epithelium with loss of cells by anoikis from the flat mucosa. Mutations in these stem cells can become embedded in the crypts, a process that is strongly implicated in CRC initiation. We describe a computational model which includes novel features, including an accurate representation of the geometry of the crypt mouth. Model simulations yield previously unseen emergent phenomena, such as localization of cell death to a small region of the crypt mouth which corresponds with that observed in vivo. A mechanism emerges in the model for regulation of crypt cellularity in response to changes in either cell proliferation rates or membrane adhesion strengths. We show that cell shape assumptions influence this behaviour, with cylinders recapitulating biology better than spheres. Potential applications of the model include determination of roles of mutations in neoplasia and exploring factors for altered crypt morphodynamics.
File Size	307040
File Format	HTM / HTML
ISSN	20545703
DOI	10.5061/dryad.800pj
Alternate Webpage(s)	https://datadryad.org/stash/downloads/file_stream/31175
Language	English
Publisher Date	2017-10-05
Access Restriction	Open
Subject Keyword	Agent Based Model Anoikis Colonic Crypt Cell Shape Agent Based Modelling Colorectal Crypt
Content Type	Text
Resource Type	Data Set
Subject	Multidisciplinary

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