NDLI: Data from: Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in domestic cats, cheetahs and Gir lions. (Dataset)

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Data from: Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in domestic cats, cheetahs and Gir lions. (Dataset)

Content Provider	Dryad
Author	Morris, Katrina M. Kirby, Katherine Beatty, Julia A. Barrs, Vanessa R. Cattley, Sonia David, Victor O'Brien, Stephen J. Menotti-Raymond, Marilyn Belov, Katherine
Abstract	Diversity within the major histocompatibility complex (MHC) reflects the immunological fitness of a population. MHC-linked microsatellite markers provide a simple and inexpensive method for studying MHC diversity in large scale studies. We have developed six MHC-linked microsatellite markers in the domestic cat and used these, in conjunction with five neutral microsatellites, to assess MHC diversity in domestic mixed breed (n = 129) and purebred Burmese (n = 61) cat populations in Australia. The MHC of outbred Australian cats is polymorphic (average allelic richness = 8.52) while the Burmese population has much significantly lower MHC diversity (average allelic richness = 6.81; P<0.01). The MHC-linked microsatellites along with MHC cloning and sequencing demonstrated moderate MHC diversity in cheetahs (n = 13) and extremely low diversity in Gir lions (n = 13). Our MHC-linked microsatellite markers have potential future use in diversity and disease studies in other populations and breeds of cats as well as in wild felid species.
File Size	70472
File Format	HTM / HTML
ISSN	00221503
DOI	10.5061/dryad.7mt1t
Alternate Webpage(s)	https://datadryad.org/stash/downloads/file_stream/65513
Alternate Webpage(s)	https://datadryad.org/stash/downloads/file_stream/65510
Alternate Webpage(s)	https://datadryad.org/stash/downloads/file_stream/65511
Alternate Webpage(s)	https://datadryad.org/stash/downloads/file_stream/65512
Language	English
Publisher Date	2014-02-06
Access Restriction	Open
Subject Keyword	Disease Population Structure and Phylogeography Acinonyx Jubatus Felis Catus
Content Type	Text
Resource Type	Data Set
Subject	Genetics Molecular Biology Genetics (clinical) Biotechnology

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