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Data from: Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes (Dataset)
| Content Provider | Dryad |
|---|---|
| Author | Chen, Xudong Feng, Yundi Huo, Yunlong Tan, Wenchang |
| Abstract | Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a mathematical model was developed to investigate the effects of rogue RyRs on Ca2+ sparks in cardiac myocytes. Ca2+ quarks and sparks from the stochastic opening of rogue and clustered RyRs are numerically reproduced and agree with experimental measurements. It is found that the stochastic opening Ca2+ release units (CRUs) of clustered RyRs are regulated by free Ca2+ concentration in the JSR lumen (i.e. [Ca2+]lumen). The frequency of spontaneous Ca2+ sparks is remarkably increased by the rogue RyRs opening at high [Ca2+]lumen, but not at low [Ca2+]lumen. Hence, the opening of rogue RyRs contributes to the formation of Ca2+ sparks at high [Ca2+]lumen. The interplay of Ca2+ sparks and Ca2+ quarks has been discussed in detail. This work is of significance to provide insight into understanding Ca2+ release mechanisms in cardiac myocytes. |
| File Size | 53887 |
| File Format | HTM / HTML |
| ISSN | 20545703 |
| DOI | 10.5061/dryad.2s2g2 |
| Alternate Webpage(s) | https://datadryad.org/stash/downloads/file_stream/53776 |
| Language | English |
| Publisher Date | 2018-01-18 |
| Access Restriction | Open |
| Subject Keyword | $ca^{2+}$ Quark Rogue Ryanodine Receptors Anomalous Subdiffusion Ca2+ Spark Ca2+ Quark $ca^{2+}$ Spark |
| Content Type | Text |
| Resource Type | Data Set |
| Subject | Multidisciplinary |
