The protective effect of piperine on ovariectomy induced bone loss in female mice and its enhancement effect of osteogenic differentiation via Wnt/β-catenin signaling pathway

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Zhong Zuo Chenrui Li Weiyun Yao Yu Li Lixiu Zhang Shu Zhang
Abstract	Piperine (PIP) demonstrates extensive pharmacological effects. Recent studies reported that PIP enhanced osteogenic differentiation and inhibited osteoclast functions. Nevertheless, its effect has not been evaluated in vivo. In the current study, ovariectomised female mice and MC3T3-E1 cells were used to examine its effect on osteoblastogenesis. Oral administration of PIP significantly elevated bone mineral density and suppressed bone remodeling without dose dependence. The deterioration of trabecula and biomechanical properties were significantly improved. Moreover, new bone formation was also accelerated with increased mineral apposition rate. At the presence of PIP, the cell proliferation and alkaline phosphatase as well as mineralized nodules formation were significantly enhanced. The expression of osteogenic markers and Wnt/β-catenin signals were significantly up-regulated by the treatment of PIP. Conclusively, as an alternative supplement or functional food ingredient, PIP has the potential to treat osteoporosis induced by estrogen deficiency by enhancing osteogenic differentiation via Wnt/β-catenin signaling.
Related Links	http://www.sciencedirect.com/science/article/pii/S1756464619302324
ISSN	17564646
e-ISSN	22149414
DOI	10.1016/j.jff.2019.04.048
Journal	Journal of Functional Foods
Volume Number	58
Language	English
Publisher	Elsevier
Publisher Date	2019-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Nutrition. Foods and Food Supply Piperine Ovariectomized Mice Wnt/β-catenin Osteoblast Bone Remodeling
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine Food Science