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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Agustin Gonzalez-Vicente Nancy J. Hong Nianxin Yang Pablo D. Cabral Jessica M. Berthiaume Fernando P. Dominici Jeffrey L. Garvin |
| Abstract | Dietary fructose causes salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the filtered NaCl. Angiotensin II (Ang II), atrial natriuretic peptide (ANP) and norepinephrine (NE) regulate this process. Although Ang II signaling blockade ameliorates fructose-induced salt-sensitive hypertension, basal PT Na+ reabsorption and its sensitivity to the aforementioned factors have not been studied in this model. We hypothesized consuming fructose with a high-salt diet selectively enhances the sensitivity of PT transport to Ang II. We investigated the effects of Ang II, ANP and NE on PT Na reabsorption in rats fed a high-salt diet drinking tap water (HS) or 20% fructose (HS-FRU). Oxygen consumption (QO2) was used as a measure of all ATP-dependent transport processes. Na+/K+-ATPase and Na+/H+-exchange (NHE) activities were studied because they represent primary apical and basolateral transporters in this segment. The effect of 10−12 mol/L Ang II in QO2 by PTs from HS-FRU was larger than HS (p < 0.02; n = 7). In PTs from HS-FRU 10−12 mol/L Ang II stimulated NHE activity by 2.6 ± 0.7 arbitrary fluorescence units/s (p < 0.01; n = 5) but not in those from HS. The stimulatory effect of Ang II on PT Na+/K+-ATPase activity was not affected by HS-FRU. Responses of QO2 and NHE activity to ANP did not differ between groups. The response of QO2 to NE was unaltered by HS-FRU. We concluded that the sensitivity of PT Na+ reabsorption specifically to Ang II is enhanced by HS-FRU. This maintains high rates of transport even in the presence of low concentrations of the peptide, and likely contributes to the hypertension. |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu10091244 |
| Journal | Nutrients |
| Issue Number | 9 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI AG |
| Publisher Date | 2018-09-01 |
| Publisher Place | Switzerland |
| Access Restriction | Open |
| Subject Keyword | Nutrition. Foods and Food Supply Kidney Blood Pressure Salt Sensitivity Na+/h+ Exchange Na+/k+-atpase Atrial Natriuretic Peptide Norepinephrine Sodium Excretion |
| Content Type | Text |
| Resource Type | Article |
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