NDLI: Diffusion weighted MRI and transient elastography assessment of liver fibrosis in hepatitis C patients: Validity of non invasive imaging techniques

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Diffusion weighted MRI and transient elastography assessment of liver fibrosis in hepatitis C patients: Validity of non invasive imaging techniques

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Fatma Zaiton Hitham Dawoud Inas M. El Fiki Khaled M. Hadhoud
Abstract	Objective: Treatment for hepatitis C infection and monitoring of progression were based on degree of fibrosis, which were traditionally diagnosed by liver biopsy but it has many limitations. We aim to evaluate noninvasive imaging methods, so-called diffusion-weighted MRI (DW MRI) and transient elastography [(TE), fibroscan] in diagnosing liver fibrosis in hepatitis C (HCV) patients. Patients: The Study included 102 hepatitis C patients (62 male) with mean age of 38 ± 5. For all patients liver biopsy was done followed by DW MRI and TE. METAVIR classification system was used for staging liver fibrosis. Data obtained were collected and results of DW MRI and TE were compared with those of histopathology. The diagnostic performance of ADC and TE was determined using areas under receiver operating characteristic (AUROC) curves for significant fibrosis ⩾F3. Results: Measuring ADC at different b-values had a significant negative correlation with stage of fibrosis P = 0.001, the best negative correlation at b-value of 700 mm2/s. TE had a significant positive correlation with stage of fibrosis P = 0.005. Both examination showed a significant difference between fibrosis stage
Related Links	http://www.sciencedirect.com/science/article/pii/S0378603X14000357
ISSN	0378603X
e-ISSN	20904762
DOI	10.1016/j.ejrnm.2014.02.007
Journal	The Egyptian Journal of Radiology and Nuclear Medicine
Issue Number	2
Volume Number	45
Language	English
Publisher	SpringerOpen
Publisher Date	2014-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Medical Physics. Medical Radiology. Nuclear Medicine Hepatitis C Liver Fibrosis Diffusion Weighted Mri Ultrasound Elastography
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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