NDLI: Beneficial effects of anthocyanins from red cabbage (Brassica oleracea L. var. capitata L.) administration to prevent irinotecan-induced mucositis

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Beneficial effects of anthocyanins from red cabbage (Brassica oleracea L. var. capitata L.) administration to prevent irinotecan-induced mucositis

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Tao Tong Yun-Hui Niu Yuan Yue Shuang-chan Wu Hong Ding
Abstract	Intestinal mucositis is a common side effect of Irinotecan (CPT-11). Anthocyanins (ACs) from red cabbage against CPT-11-induced mucositis were studied. Mice were given CPT-11 (75 mg/kg, i.p. for 4 days) and treated with ACs (50, 100 mg/kg, i.g. for 7 days). On day 8, diarrhea and leukocyte count in blood were assessed. Samples of intestine were obtained for morphometric analysis, myeloperoxidase (MPO), TBARS and GSH assay. The effects of ACs on cytoprotection and intestinal permeability were studied in Caco-2 cells. ACs effectively reversed the signs of intestinal injury, including MPO activity, length of ileum and colon, leukopenia, intestinal architecture, and quantity of ileum mucus. In vitro, pretreatment with ACs enhanced transepithelial electrical resistance (TER) and the expression of ZO-1. Furthermore, the protective effects of ACs were associated to modulate autophagy through mTOR pathway. In conclusion, ACs from red cabbage are candidate for supplementary therapy of CPT-11-induced mucositis.
Related Links	http://www.sciencedirect.com/science/article/pii/S1756464617300610
ISSN	17564646
e-ISSN	22149414
DOI	10.1016/j.jff.2017.01.051
Journal	Journal of Functional Foods
Volume Number	32
Language	English
Publisher	Elsevier
Publisher Date	2017-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Nutrition. Foods and Food Supply Anthocyanins Autophagy Irinotecan Mtor Mucositis Red Cabbage
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine Food Science

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