NDLI: Identification of prognostic gene expression signatures based on the tumor microenvironment characterization of gastric cancer

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Qingqing Sang Wentao Dai Junxian Yu Yunqin Chen Zhiyuan Fan Jixiang Liu Fangyuan Li Jianfang Li Xiongyan Wu Junyi Hou Beiqin Yu Haoran Feng Zheng-Gang Zhu Liping Su Yuan-Yuan Li Bingya Liu
Abstract	Increasing evidence has elucidated that the tumor microenvironment (TME) shows a strong association with tumor progression and therapeutic outcome. We comprehensively estimated the TME infiltration patterns of 111 gastric cancer (GC) and 21 normal stomach mucosa samples based on bulk transcriptomic profiles based on which GC could be clustered as three subtypes, TME-Stromal, TME-Mix, and TME-Immune. The expression data of TME-relevant genes were utilized to build a GC prognostic model—GC_Score. Among the three GC TME subtypes, TME-Stomal displayed the worst prognosis and the highest GC_Score, while TME-Immune had the best prognosis and the lowest GC_Score. Connective tissue growth factor (CTGF), the highest weighted gene in the GC_Score, was found to be overexpressed in GC. In addition, CTGF exhibited a significant correlation with the abundance of fibroblasts. CTGF has the potential to induce transdifferentiation of peritumoral fibroblasts (PTFs) to cancer-associated fibroblasts (CAFs). Beyond characterizing TME subtypes associated with clinical outcomes, we correlated TME infiltration to molecular features and explored their functional relevance, which helps to get a better understanding of carcinogenesis and therapeutic response and provide novel strategies for tumor treatments.
e-ISSN	16643224
DOI	10.3389/fimmu.2022.983632
Journal	Frontiers in Immunology
Volume Number	13
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2022-08-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Immunologic Diseases. Allergy Gastric Cancer Tumor Microenvironment Prognostic Model Ctgf Fibroblasts
Content Type	Text
Resource Type	Article

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