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Content Provider | Directory of Open Access Journals (DOAJ) |
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Author | Diego Oliva-Rico Eunice Fabian-Morales Rodrigo E. Cáceres-Gutiérrez Adriana Gudiño Fernanda Cisneros-Soberanis Julieta Dominguez Oscar Almaraz-Rojas Cristian Arriaga-Canon Clementina Castro-Hernández Carlos De la Rosa José L. Reyes Luis A. Herrera |
Abstract | The long noncoding RNA (lncRNA) telomeric repeat-containing RNA (TERRA) has been associated with telomeric homeostasis, telomerase recruitment, and the process of chromosome healing; nevertheless, the impact of this association has not been investigated during the carcinogenic process. Determining whether changes in TERRA expression are a cause or a consequence of cell transformation is a complex task because studies are usually carried out using either cancerous cells or tumor samples. To determine the role of this lncRNA in cellular aging and chromosome healing, we evaluated telomeric integrity and TERRA expression during the establishment of a clone of untransformed myeloid cells. We found that reduced expression of TERRA disturbed the telomeric homeostasis of certain loci, but the expression of the lncRNA was affected only when the methylation of subtelomeric bivalent chromatin domains was compromised. We conclude that the disruption in TERRA homeostasis is a consequence of cellular transformation and that changes in its expression profile can lead to telomeric and genomic instability. |
ISSN | 16616596 |
e-ISSN | 14220067 |
DOI | 10.3390/ijms23063271 |
Journal | International Journal of Molecular Sciences |
Issue Number | 6 |
Volume Number | 23 |
Language | English |
Publisher | MDPI AG |
Publisher Date | 2022-03-01 |
Publisher Place | Switzerland |
Access Restriction | Open |
Subject Keyword | Biology (general) Chemistry Telomeres Terra Lncrna Htert |
Content Type | Text |
Resource Type | Article |
Subject | Spectroscopy Organic Chemistry Medicine Molecular Biology Physical and Theoretical Chemistry Catalysis Inorganic Chemistry Computer Science Applications |
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