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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Wenfei Bo Lianghao Guo Yang Yang Jialu Ma Kaicheng Wang Jingchao Tang Zhe Wu Baoqing Zeng Yubin Gong |
| Abstract | This paper simulates $Ca^{2+}$ transmembrane transport through voltage-gated $Ca^{2+}$ channels in response to terahertz electromagnetic irradiation. The active transport of $Ca^{2+}$ ions is taken into considerations in the $Ca^{2+}$ transport. Temperature variations due to terahertz electromagnetic loss in physiological medium are simulated. The electromagnetic interaction between terahertz fields and physiological mobile ions at the cellular level is deduced from relativistic electrodynamics. It shows that effects of 0.1 ~ 3 THz electromagnetic fields on cell mobile ions are primarily due to effects of electric fields, and effects of magnetic fields at the cellular level are insignificant. In addition, numerical simulation reveals that terahertz irradiation causes vibration of membrane potential, which is able to activate voltage-gated $Ca^{2+}$ channels. Besides, bioeffects of terahertz frequency, irradiation duration and electric intensity on the increment of intracellular $Ca^{2+}$ concentration due to activation of voltage-gated $Ca^{2+}$ channels are revealed. Meanwhile, numerical results show that temperature rises are inconsequential in the case of different irradiation parameters, indicating the non-thermal bioeffects of voltage-gated $Ca^{2+}$ transmembrane transport due to terahertz irradiation. Furthermore, the results also reveal that thermal bioeffect can be significant if the irradiation duration is raised long enough for high-dose terahertz irradiation. The numerical simulations lay the basis for understanding the bioeffects of terahertz irradiation on $Ca^{2+}$ transmembrane transport and pave the way for further exploration in modulation of intracellular $Ca^{2+}$ concentration with terahertz electromagnetic wave. |
| e-ISSN | 21693536 |
| DOI | 10.1109/ACCESS.2020.2964780 |
| Journal | IEEE Access |
| Volume Number | 8 |
| Language | English |
| Publisher | IEEE |
| Publisher Date | 2020-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Electrical Engineering. Electronics. Nuclear Engineering Biological Effects of Electromagnetic Radiation Modeling and Simulations Calcium Ions Voltage-gated Calcium Channel Active Transport |
| Content Type | Text |
| Resource Type | Article |
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