NDLI: Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet

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Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Aziza A. El-Nekeety Sekena H. Abdel-Azeim Aziza M. Hassan Nabila S. Hassan Soher E. Aly Mosaad A. Abdel-Wahhab
Abstract	This study was conducted to evaluate the protective role of quercetin (Q) against the cytotoxicity, DNA damage and oxidative stress in rats fed aflatoxin (AFs)-contaminated diet. Female Sprague–Dawley rats were divided into six groups and treated for 21 days as follows: the control group; the group fed AFs-contaminated diet (1.4 mg/kg diet); the groups treated orally with Q at low or high dose (50 and 100 mg/kg b.w.) and the groups AFs-contaminated diet plus low or high dose of Q. At the end of experiment, blood and liver samples were collected for biochemical, histological, histochemical and genetic analyses. The results indicated that animal fed AFs-contaminated diet showed significant increase in serum biochemical parameters, oxidative stress markers and DNA fragmentation accompanied with significant decrease in total proteins, GPX, SOD, DNA and RNA content and fatty acid synthase (Fas) and TNFα gene expression in the liver tissue. Q at the two tested doses s쳮ded to normalize the biochemical parameters, improved the content of nucleic acids in hepatic tissues, the gene expression, the histopathological and histochemical picture of the liver. It could be concluded that Q has a potential antioxidant activity, a protective action and regulated the alteration of genes expression induced by AFs.
Related Links	http://www.sciencedirect.com/science/article/pii/S2214750014000353
ISSN	22147500
DOI	10.1016/j.toxrep.2014.05.014
Journal	Toxicology Reports
Issue Number	C
Volume Number	1
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Toxicology. Poisons Aflatoxin Liver Quercetin Cytogenetic Gene Expression Oxidative Stress
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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