New mesostructured origami silica matrix: a nano-platform for highly retentive and pH-controlled delivery system

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Mirza Mahmood Baig Muhammad Asif Yousuf Ibrahim A. Alsafari Muhammad Ali Philips O. Agboola Imran Shakir Sajjad Haider Muhammad Farooq Warsi
Abstract	In the present study, stabilizer caged fluorescent rhodamine B mesoporous silica particles with special shapes were prepared. The prepared particles have a pore volume of 1.92 cm3/g and a pore diameter of 12 nm. The abundant hydroxyl functional groups of mesoporous silica are responsible for the superior loading capacity of target molecular specie. The appearance of bands due to –COOH, –CH3, –CH2, –NH etc. indicated that the fluorescent rhodamine B could be encaged with the stabilizer inside the mesoporous channels. The performance of mesostructured origami silica matrix was evaluated by in vitro release experiments. From the in vitro release results, this material is suggested to have appropriate features for almost no release at pH = 1.2 and very slow release at neutral pH value. The same material could be best employed at pH 4.5 and at high pH values. It is concluded that mesostructured origami silica matrix is a smart nano-platform and can be utilized for high retention of cargo molecules.
Related Links	http://dx.doi.org/10.1080/16583655.2021.1902176
e-ISSN	16583655
DOI	10.1080/16583655.2021.1902176
Journal	Journal of Taibah University for Science
Issue Number	1
Volume Number	15
Language	English
Publisher	Taylor & Francis Group
Publisher Date	2021-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Science (General) Silica Matrix Rhodamine B Mesoporous Silica Particles in Vitro Ph Results Ftir Sem Edx
Content Type	Text
Resource Type	Article