Regioselective synthesis of anilines and β-dibrominated acetamides from N-aryl acetoacetamides mediated by Cu(I) salts

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Li-Quan Tan Wei-Bing Liu Peng Zhou Cui Chen Qing Zhang
Abstract	A highly regioselective synthetic strategy mediated by Cu(I) salts is presented for the synthesis of anilines and β-dibrominated acetamides from N-aryl acetoacetamides. A variety of N-aryl acetoacetamides were used in this protocol, and a wide range of polysubstituted anilines and β-dibrominated acetamides were obtained in moderate to good yields. When employing CuI as the additive in this strategy, anilines are obtained, however, when using CuBr as the partner of CuI under a mild condition, β-dibrominated acetamides are afforded.
Related Links	http://www.sciencedirect.com/science/article/pii/S1319610314000507
ISSN	13196103
DOI	10.1016/j.jscs.2014.03.004
Journal	Journal of Saudi Chemical Society
Issue Number	2
Volume Number	20
Language	English
Publisher	Elsevier
Publisher Date	2016-01-01
Publisher Place	Saudi Arabia
Access Restriction	Open
Subject Keyword	Chemistry Anilines Β-dibrominated Acetamides Regioselective Synthesis Cleavage of Carbon–carbon Bond Cleavage of Carbon–nitrogen Bond
Content Type	Text
Resource Type	Article
Subject	Chemistry