NDLI: Prevention of Torsade de Pointes during the Pharmacologic Treatment of Atrial Fibrillation

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Prevention of Torsade de Pointes during the Pharmacologic Treatment of Atrial Fibrillation

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Hideo Mitamura
Abstract	Potassium channel blockers are sometimes effective in the rhythm management of persistent atrial fibrillation. However, on rare occasions, a life-threatening episode of torsade de pointes develops during treatment with these agents. Among several precautions against this tragedy, preventing exaggerated QT prolongation is of paramount importance. One of the difficulties in monitoring the QT interval during atrial fibrillation is the fact that its length varies depending not only on the fluctuating preceding intervals, but on other factors such as neurohumoral activation. In fact, even at the same preceding RR interval, the QT interval may vary from day to night, between atrial fibrillation and sinus rhythm. Accordingly, the QTc interval may not be a reliable parameter for predicting proarrhythmic events. As the result, close monitoring of the QT interval itself, just like INR monitoring during warfarin treatment, is mandatory both before and during treatment with these agents.
Related Links	http://www.sciencedirect.com/science/article/pii/S1880427610800304
ISSN	18804276
DOI	10.1016/S1880-4276(10)80030-4
Journal	Journal of Arrhythmia
Issue Number	1
Volume Number	26
Language	English
Publisher	Wiley
Publisher Date	2010-01-01
Publisher Place	Australia
Access Restriction	Open
Subject Keyword	Diseases of the circulatory (Cardiovascular) system Torsade De Pointes Atrial Fibrillation Qt Interval Antiarrhythmic Drug
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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