NDLI: Genome-wide association scan for variants associated with early-onset prostate cancer.

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Ethan M. Lange Anna M. Johnson Yunfei Wang Kimberly A. Zuhlke Yurong Lu Jessica V. Ribado Gregory R. Keele Jin Li Qing Duan Ge Li Zhengrong Gao Yun Li Jianfeng Xu William B. Isaacs Siqun Zheng Kathleen A. Cooney
Abstract	Prostate cancer is the most common non-skin cancer and the second leading cause of cancer related mortality for men in the United States. There is strong empirical and epidemiological evidence supporting a stronger role of genetics in early-onset prostate cancer. We performed a genome-wide association scan for early-onset prostate cancer. Novel aspects of this study include the focus on early-onset disease (defined as men with prostate cancer diagnosed before age 56 years) and use of publically available control genotype data from previous genome-wide association studies. We found genome-wide significant (p<5×10(-8)) evidence for variants at 8q24 and 11p15 and strong supportive evidence for a number of previously reported loci. We found little evidence for individual or systematic inflated association findings resulting from using public controls, demonstrating the utility of using public control data in large-scale genetic association studies of common variants. Taken together, these results demonstrate the importance of established common genetic variants for early-onset prostate cancer and the power of including early-onset prostate cancer cases in genetic association studies.
e-ISSN	19326203
DOI	10.1371/journal.pone.0093436
Journal	PLoS ONE
Issue Number	4
Volume Number	9
Language	English
Publisher	Public Library of Science (PLoS)
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Medicine Science
Content Type	Text
Resource Type	Article

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