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Content Provider | Directory of Open Access Journals (DOAJ) |
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Author | Miren Taberna Marisa Mena Sara Tous Miquel Angel Pavón Marc Oliva Xavier León Jacinto Garcia Marta Guix Rafael Hijano Teresa Bonfill Antón Aguilà Laia Alemany Ricard Mesía |
Abstract | Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value.The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests.A total of 788 consecutive OPC cases diagnosed from 1991 to 2013 were considered eligible for the analysis. Of these samples, 66 (8.4%) were positive for HPV-DNA and (p16INK4a or HPV-mRNA), 83 (10.5%) were p16INK4a positive and 58 (7.4%) were double positive for HPV-DNA/p16INK4a. ICON-S model was the staging system, which performed better in our series when using at least two biomarkers to define HPV-causality. When the same analysis was performed considering only p16INK4a-positivity, RPA stage with non-anatomic factors (Princess Margaret) has the best classification based on AIC criteria.HPV-relatedness definition for classifying HPV-related OPC patient do impact on TNM classification and patients' survival. Further studies assessing HPV-relatedness definitions are warranted to better classify HPV-related OPC patients in the era of de-escalation clinical trials. |
e-ISSN | 19326203 |
DOI | 10.1371/journal.pone.0194107 |
Journal | PLoS ONE |
Issue Number | 4 |
Volume Number | 13 |
Language | English |
Publisher | Public Library of Science (PLoS) |
Publisher Date | 2018-01-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Medicine Science |
Content Type | Text |
Resource Type | Article |
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