NDLI: A Novel Delivery System for the Controlled Release of Antimicrobial Peptides: Citropin 1.1 and Temporin A

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A Novel Delivery System for the Controlled Release of Antimicrobial Peptides: Citropin 1.1 and Temporin A

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A Novel Delivery System for the Controlled Release of Antimicrobial Peptides: Citropin 1.1 and Temporin A

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Urszula Piotrowska Ewa Oledzka Anna Zgadzaj Marta Bauer Marcin Sobczak
Abstract	Antimicrobial peptides (AMPs) are prospective therapeutic options for treating multiple-strain infections. However, clinical and commercial development of AMPs has some limitations due to their limited stability, low bioavailability, and potential hemotoxicity. The purpose of this study was to develop new polymeric carriers as highly controlled release devices for amphibian peptides citropin 1.1 (CIT) and temporin A (TEMP). The release rate of the active pharmaceutical ingredients (APIs) was strongly dependent on the API characteristics and the matrix microstructure. In the current work, we investigated the effect of the polymer microstructure on in vitro release kinetics of AMPs. Non-contact laser profilometry, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) were used to determine the structural changes during matrix degradation. Moreover, geno- and cytotoxicity of the synthesized new carriers were evaluated. The in vitro release study of AMPs from the obtained non-toxic matrices shows that peptides were released with near-zero-order kinetics. The peptide “burst release” effect was not observed. New devices have reached the therapeutic concentration of AMPs within 24 h and maintained it for 28 days. Hence, our results suggest that these polymeric devices could be potentially used as therapeutic options for the treatment of local infections.
e-ISSN	20734360
DOI	10.3390/polym10050489
Journal	Polymers
Issue Number	5
Volume Number	10
Language	English
Publisher	MDPI AG
Publisher Date	2018-05-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Organic Chemistry Antimicrobial Peptides Biodegradable Polymers Biocompatible Polymers Drug Delivery Systems Controlled Release Citropin Temporin Ionic Liquids
Content Type	Text
Resource Type	Article

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