NDLI: Preoptic leptin signaling modulates energy balance independent of body temperature regulation

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Sangho Yu Helia Cheng Marie François Emily Qualls-Creekmore Clara Huesing Yanlin He Yanyan Jiang Hong Gao Yong Xu Andrea Zsombok Andrei V. Derbenev Eduardo A. Nillni David H. Burk Christopher D. Morrison Hans-Rudolf Berthoud Heike Münzberg
Abstract	The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice. We show that POA Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis. However, POA leptin signaling is not involved in ambient temperature-dependent metabolic adaptations. Our study reveals a novel cell population through which leptin regulates body weight.
e-ISSN	2050084X
DOI	10.7554/eLife.33505
Journal	eLife
Volume Number	7
Language	English
Publisher	eLife Sciences Publications Ltd
Publisher Date	2018-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Medicine Science Biology (general) Knockdown Body Weight Energy Expenditure Food Intake High Fat Diet Preoptic Area
Content Type	Text
Resource Type	Article

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