NDLI: Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

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Year: 2022, Volume: 11

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Year: 2021, Volume: 10

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Transgenerational inheritance of ethanol preference is caused by maternal NPF repression

Fly model sheds light on brain disease

Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Gut microbiota density influences host physiology and is shaped by host and microbial factors

Modular organization of cerebellar climbing fiber inputs during goal-directed behavior

Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobin

Free circular introns with an unusual branchpoint in neuronal projections

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

Stem cell topography splits growth and homeostatic functions in the fish gill

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

The cellular basis of mechanosensory Merkel-cell innervation during development

Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive

Identification of potential biomarkers of vaccine inflammation in mice

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

Population adaptation in efficient balanced networks

Molecular basis of wax-based color change and UV reflection in dragonflies

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

Ion counting demonstrates a high electrostatic field generated by the nucleosome

Human perivascular stem cell-derived extracellular vesicles mediate bone repair

MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

Demographic reconstruction from ancient DNA supports rapid extinction of the great auk

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

Hypothesis, analysis and synthesis, it's all Greek to me

Large-scale state-dependent membrane remodeling by a transporter protein

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

Anterior insular cortex plays a critical role in interoceptive attention

Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars

mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

Insulin-like peptides and the mTOR-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death

Subcellular drug targeting illuminates local kinase action

Valence-encoding in the lateral habenula arises from the entopeduncular region

Tell me a story

Extensive ribosome and RF2 rearrangements during translation termination

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

Progress and promise

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

An arbitrary-spectrum spatial visual stimulator for vision research

Connexin-43-dependent ATP release mediates macrophage activation during sepsis

Uncovering the secret life of Rho GTPases

Epigenetic silencing of a multifunctional plant stress regulator

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

Ribosome biogenesis restricts innate immune responses to virus infection and DNA

Characterizing causality in cancer

Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

Bichir external gills arise via heterochronic shift that accelerates hyoid arch development

Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Quorums enable optimal pooling of independent judgements in biological systems

Non-canonical RNA-directed DNA methylation participates in maternal and environmental control of seed dormancy

Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells

Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

Suppression of transcytosis regulates zebrafish blood-brain barrier function

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

Multistability and regime shifts in microbial communities explained by competition for essential nutrients

Ten common statistical mistakes to watch out for when writing or reviewing a manuscript

The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

Single-cell proteomics reveals changes in expression during hair-cell development

A toolkit for studying cell surface shedding of diverse transmembrane receptors

The structure of the endogenous ESX-3 secretion system

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

Epigenetic memory independent of symmetric histone inheritance

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

Kinesin and dynein use distinct mechanisms to bypass obstacles

An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

Functional proteomic atlas of HIV infection in primary human CD4+ T cells

In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

An order-to-disorder structural switch activates the FoxM1 transcription factor

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death

Improved characterisation of MRSA transmission using within-host bacterial sequence diversity

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome

Confidence predicts speed-accuracy tradeoff for subsequent decisions

Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

A survey of new PIs in the UK

Phage integration alters the respiratory strategy of its host

The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

Tonotopic and non-auditory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging

Inadequate BiP availability defines endoplasmic reticulum stress

Common activation mechanism of class A GPCRs

Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

Finding the fish factor

The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

Correction: Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats

Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

Anosognosia for hemiplegia as a tripartite disconnection syndrome

β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

Unimodal statistical learning produces multimodal object-like representations

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

Non-enzymatic primer extension with strand displacement

Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

Associations between sounds and actions in early auditory cortex of nonhuman primates

The importance of methionine metabolism

Retraction: Pyrophosphate modulates plant stress responses via SUMOylation

Antagonism between parasites within snail hosts impacts the transmission of human schistosomiasis

Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features

A single K+-binding site in the crystal structure of the gastric proton pump

Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

Long-term consequences of the absence of leptin signaling in early life

Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

A generalized theory of age-dependent carcinogenesis

5α-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia

Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

Correction: Imaging neuropeptide release at synapses with a genetically engineered reporter

A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

A novel lineage of candidate pheromone receptors for sex communication in moths

Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

Silencing the alternative

Real time dynamics of Gating-Related conformational changes in CorA

Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation

Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Nitric oxide radicals are emitted by wasp eggs to kill mold fungi

Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

De novo design of a homo-trimeric amantadine-binding protein

Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors

Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep

Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

Modularity, criticality, and evolvability of a developmental gene regulatory network

Catecholaminergic modulation of meta-learning

Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

Bridging the gap between single-cell migration and collective dynamics

Does disease start in the mouth, the gut or both?

Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

Balancing model-based and memory-free action selection under competitive pressure

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

Emergence of trait variability through the lens of nitrogen assimilation in Prochlorococcus

A new class of disordered elements controls DNA replication through initiator self-assembly

High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

Length-dependent disassembly maintains four different flagellar lengths in Giardia

Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry

Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

Phylodynamic theory of persistence, extinction and speciation of rapidly adapting pathogens

Too hip for two sacral vertebrae

A de novo evolved gene in the house mouse regulates female pregnancy cycles

Leave-One-Trial-Out, LOTO, a general approach to link single-trial parameters of cognitive models to neural data

Neural precursors of decisions that matter—an ERP study of deliberate and arbitrary choice

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

Imaging neuropeptide release at synapses with a genetically engineered reporter

An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Single-molecule turnover dynamics of actin and membrane coat proteins in clathrin-mediated endocytosis

Indirect sexual selection drives rapid sperm protein evolution in abalone

Rapid learning and unlearning of predicted sensory delays in self-generated touch

Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

Balance between BDNF and Semaphorins gates the innervation of the mammary gland

Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

A new home for microbes

MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

The nature of the animacy organization in human ventral temporal cortex

Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

Uncovering the functional anatomy of the human insula during speech

Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

Centralized scientific communities are less likely to generate replicable results

The ion selectivity filter is not an activation gate in TRPV1-3 channels

Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

Molecular structures of the human Slo1 K+ channel in complex with β4

Har-P, a short P-element variant, weaponizes P-transposase to severely impair Drosophila development

Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties

DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

Common concepts for bacterial collectives

Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

The SNAP-25 linker supports fusion intermediates by local lipid interactions

Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

Spatiotemporal organization of branched microtubule networks

Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

Intergenerational effects of early adversity on survival in wild baboons

Region-specific regulation of stem cell-driven regeneration in tapeworms

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

Length regulation of multiple flagella that self-assemble from a shared pool of components

Hemozoin produced by mammals confers heme tolerance

Pyrophosphate modulates plant stress responses via SUMOylation

Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

Attentional amplification of neural codes for number independent of other quantities along the dorsal visual stream

Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Optimal searching behaviour generated intrinsically by the central pattern generator for locomotion

Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling

HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

Building a better model of the retina

Immune genes are hotspots of shared positive selection across birds and mammals

The structure of the Ctf19c/CCAN from budding yeast

Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

Correction: Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

Dystroglycan is a scaffold for extracellular axon guidance decisions

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis

Opto-magnetic capture of individual cells based on visual phenotypes

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

Learning to generalize

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern

Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

The molecular architecture of engulfment during Bacillus subtilis sporulation

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

C-mannosylation supports folding and enhances stability of thrombospondin repeats

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn

Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

Estimating effectiveness of case-area targeted response interventions against cholera in Haiti

A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Correlated evolution between repertoire size and song plasticity predicts that sexual selection on song promotes open-ended learning

Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

'Palaeoshellomics' reveals the use of freshwater mother-of-pearl in prehistory

Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA

Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output

Modular transcriptional programs separately define axon and dendrite connectivity

Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis

An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

Voluntary and involuntary contributions to perceptually guided saccadic choices resolved with millisecond precision

Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin

Rare variants contribute disproportionately to quantitative trait variation in yeast

Exploring atypical timescales in the brain

Causal links between parietal alpha activity and spatial auditory attention

Host-pathogen coevolution increases genetic variation in susceptibility to infection

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

A multidisciplinary approach to a unique palaeolithic human ichnological record from Italy (Bàsura Cave)

Retraction: The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA

Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore

Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish

Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

Distinct roles of striatal direct and indirect pathways in value-based decision making

Correction: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

Nuclear genetic regulation of the human mitochondrial transcriptome

Functional clustering of dendritic activity during decision-making

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

Looking inside an injection system

Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

Correction: Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes

The impact of light during the night

Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system

When it comes to teaching and tenure it is time to walk the walk

The meanings of 'function' in biology and the problematic case of de novo gene emergence

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss

Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

Neural structure mapping in human probabilistic reward learning

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

A β-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts

Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

Opioids modulate an emergent rhythmogenic process to depress breathing

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning in Drosophila

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors

Enteropathogen antibody dynamics and force of infection among children in low-resource settings

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Design of biochemical pattern forming systems from minimal motifs

Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

Regulation of subcellular dendritic synapse specificity by axon guidance cues

Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex

Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing

Correction: Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi

The influence of task outcome on implicit motor learning

The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals

A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

High-throughput synapse-resolving two-photon fluorescence microendoscopy for deep-brain volumetric imaging in vivo

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

Fatigue induces long-lasting detrimental changes in motor-skill learning

Structural insights into SETD3-mediated histidine methylation on β-actin

Linking spatial patterns of terrestrial herbivore community structure to trophic interactions

Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

Molecular safeguarding of CRISPR gene drive experiments

The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

Parental vaccination to reduce measles immunity gaps in Italy

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome

Elevating acetyl-CoA levels reduces aspects of brain aging

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Seminal fluid compromises visual perception in honeybee queens reducing their survival during additional mating flights

A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

Neural tracking of speech mental imagery during rhythmic inner counting

Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community

Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

Learning is enhanced by tailoring instruction to individual genetic differences

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

Antigen receptor control of methionine metabolism in T cells

Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

Tooth fracture frequency in gray wolves reflects prey availability

Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

Disordered breathing in a mouse model of Dravet syndrome

Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Electron cryo-microscopy of bacteriophage PR772 reveals the elusive vertex complex and the capsid architecture

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

Targeting mutant estrogen receptors

The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

The ion channel ppk301 controls freshwater egg-laying in the mosquito Aedes aegypti

From primal scenes to synthetic cells

A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe

The challenges of big data biology

Correction: Rapid DNA replication origin licensing protects stem cell pluripotency

The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

Statistical structure of locomotion and its modulation by odors

Natural selection and repeated patterns of molecular evolution following allopatric divergence

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

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Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Morgan Thompson Ryan Bixby Robert Dalton Alexa Vandenburg John A. Calarco Adam D. Norris
Abstract	Single-cell transcriptomes are established by transcription factors (TFs), which determine a cell's gene-expression complement. Post-transcriptional regulation of single-cell transcriptomes, and the RNA binding proteins (RBPs) responsible, are more technically challenging to determine, and combinatorial TF-RBP coordination of single-cell transcriptomes remains unexplored. We used fluorescent reporters to visualize alternative splicing in single Caenorhabditis elegans neurons, identifying complex splicing patterns in the neuronal kinase sad-1. Most neurons express both isoforms, but the ALM mechanosensory neuron expresses only the exon-included isoform, while its developmental sister cell the BDU neuron expresses only the exon-skipped isoform. A cascade of three cell-specific TFs and two RBPs are combinatorially required for sad-1 exon inclusion. Mechanistically, TFs combinatorially ensure expression of RBPs, which interact with sad-1 pre-mRNA. Thus a combinatorial TF-RBP code controls single-neuron sad-1 splicing. Additionally, we find 'phenotypic convergence,' previously observed for TFs, also applies to RBPs: different RBP combinations generate similar splicing outcomes in different neurons.
e-ISSN	2050084X
DOI	10.7554/eLife.46726
Journal	eLife
Volume Number	8
Language	English
Publisher	eLife Sciences Publications Ltd
Publisher Date	2019-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Medicine Science Biology (general) Rna Splicing Single Neuron
Content Type	Text
Resource Type	Article

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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in