NDLI: A fish oil diet produces different degrees of suppression of apoB and triglyceride secretion in human apoB transgenic mouse strains

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Carol Ko Shawn M. O'Rourke Li-Shin Huang
Abstract	Human apolipoprotein B (apoB) transgenic (HuBTg) mouse strains were used to assess genetic effects on the response to fish oil (FO), a source of n-3 fatty acids. A congenic HuBTg strain of the C57BL/6 (B6) background and six F1 HuBTg strains were fed a FO for 2 weeks. Different responses of plasma lipid levels to FO were observed among these strains. In particular, plasma apoB levels changed minimally in FO-fed male B6 HuBTg mice, but increased markedly (∼40%) in FO-fed male FVB/NJ (FVB) × B6 F1 HuBTg mice. These strain differences were determined mainly by hepatic apoB secretion rates and were likely regulated by posttranscriptional mechanisms. In addition, plasma triglyceride (TG) levels were reduced (14%) in FO-fed B6 mice, but not in FVB × B6 mice. These strain differences were determined mainly by TG secretion rates, but were not due to differences in hepatic lipogenesis. Hepatic mRNA levels of acyl-CoA oxidase, reflective of peroxisomal β-oxidation rate, were increased in FO-fed B6 but not in FVB × B6 mice, which could account for the difference in TG secretion rates.In summary, differential effects of FO on plasma apoB and TG levels in B6 and FVB × B6 HuBTg mice were associated with strain differences in hepatic apoB and TG secretion and in peroxisomal β-oxidation.
ISSN	00222275
e-ISSN	15397262
DOI	10.1194/jlr.M300172-JLR200
Journal	Journal of Lipid Research
Issue Number	10
Volume Number	44
Language	English
Publisher	Elsevier
Publisher Date	2003-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Biochemistry Apolipoprotein B Secretion Low Density Lipoprotein Receptor Hepatic Lipogenesis Peroxisomal Β-oxidation Acyl-coa Oxidase
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Endocrinology

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