NDLI: Burkholderia Infections in Diabetic Section Patients Emerging as a Challenge for Physicians: A Case Series

Content Provider	Directory of Open Access Journals (DOAJ)
Author	SHUBHRANSU PATRO SUDHANSU SEKHAR PANDA DEBASHISH MISHRA SONAPURAM KEERTHI
Abstract	The genus Burkholderia comprises more than 40 species. Medically important members of this genus are Burkholderia cepacia (B.cepacia), Burkholderia pseudomallei (B.pseudomallei) and Burkholderia mallei (B.mallei). Burkholderia cepacia complex (Bcc) can cause Cepacia syndrome which includes necrotising pneumonia, respiratory failure and bacteremia in Cystic Fibrosis (CF) patients and can be fatal. B.cepacia can be potentially pathogenic in individuals with impaired host defences and can cause pneumonia, bronchiectasis, pyopneumothorax and cavitatory lesions. The clinical manifestations of Melioidosis range from localised infection to overwhelming sepsis and death with Pneumonia being the most common presentation. The most significant risk factor for Melioidosis is diabetes. Musculoskeletal Melioidosis is not common in India even though sporadic cases have been reported mostly involving soft tissues. In the present two cases of Melioidosis in diabetics who presented with septic arthritis treated with surgical debridement followed by antibiotics and two cases of Cepacia syndrome in diabetics whose hospital course was complicated by pneumothorax and Acute Respiratory Distress Syndrome (ARDS). These reports raise the concern regarding the potential severity of Burkholderia infections and prompts early diagnosis by physicians to prevent morbidity and mortality.
ISSN	2249782X
e-ISSN	0973709X
DOI	10.7860/JCDR/2019/39889.12671
Journal	Journal of Clinical and Diagnostic Research
Issue Number	3
Volume Number	13
Language	English
Publisher	JCDR Research and Publications Private Limited
Publisher Date	2019-01-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Medicine Melioidosis Cepacia Syndrome Cystic Fibrosis Pyopneumothorax
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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