Synthesis, characterization and anti-tumour activity of iron(III) Schiff base complexes with unsymmetric tetradentate ligands

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Fahmideh Shabani Lotf Ali Saghatforoush Shahriar Ghammamy
Abstract	The synthesis and characterization of two new iron(III) complexes, $[Fe(pythsalI)]Cl_{2}$ and $[Fe(pythsalBr)]Cl_{2}$ with the NSNO-donor tetradentate Schiff base ligands pythsalHX [(5–X-N-(2pyridylethylsulfanylethyl) salicylideneimine] (X = I, Br)) obtained from the inserted condensation of 1-(2-pyridyl)-3-thia-5-aminopentane with the respective derivative salicylaldehyde in a 1:1 molar ratio is reported. The iron(III) complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:2 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:2 electrolytic nature complexes. Infrared spectral data agreed with the coordination to the central metal ion through deprotonated phenolic oxygen, imine and pyridine type nitrogens and the thioether sulfur atoms. From ligand field spectral data an octahedral geometry is assigned to the iron(III) ion in all these complexes. These new compounds have showed anti-tumour activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).
Related Links	http://ajol.info/index.php/bcse/article/view/54741
ISSN	10113924
e-ISSN	1726801X
Journal	Bulletin of the Chemical Society of Ethiopia
Issue Number	2
Volume Number	24
Language	English
Publisher	Chemical Society of Ethiopia
Publisher Date	2010-01-01
Publisher Place	Ethiopia
Access Restriction	Open
Subject Keyword	Chemistry Iron(iii) Complexes Tetradentate Ligands Unsymmetric Schiff Base Nsno-donor Anti-tumour K562 Jurkat
Content Type	Text
Resource Type	Article
Subject	Chemistry