Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Seema Kembhavi Vijaya Gadage Tanuja Shet Prabhash Kumar
Abstract	Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.
Related Links	http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=591;epage=593;aulast=Gadage
ISSN	03774929
e-ISSN	09745130
DOI	10.4103/0377-4929.85104
Journal	Indian Journal of Pathology and Microbiology
Issue Number	3
Volume Number	54
Language	English
Publisher	Wolters Kluwer Medknow Publications
Publisher Date	2011-01-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Pathology Microbiology Cardiac Tumor Diffuse Large B-cell Lymphoma Non-hodgkin′s Lymphoma
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine Microbiology (medical)