Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Ufuk Turan Kursat Korkmaz Suleyman Ersoy Ahmet Yuksel Humeyra Celik Erhan Renan Ucaroglu Yusuf Velioglu Ayhan Cetinkaya Deniz Demir Umut Esen Kemalettin Erdem
Abstract	ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.
Related Links	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279&tlng=en
ISSN	15163180
e-ISSN	18069460
DOI	10.1590/1516-3180.2020.0457.r1.04022021
Journal	São Paulo Medical Journal
Issue Number	3
Volume Number	139
Language	English
Publisher	Associação Paulista de Medicina
Publisher Date	2021-01-01
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Medicine Vitamin D Venous Thrombosis 25-hydroxyvitamin D3 1-alpha-hydroxylase Deep Vein Thrombosis Deep Venous Thromboses 25(oh)d 25-hydroxyvitamin D3 Thrombosis, Deep Vein
Content Type	Text
Resource Type	Article
Subject	Medicine