NDLI: In vitro wound healing activity of luteolin

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In vitro wound healing activity of luteolin

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Z. Bayrami F. Khalighi-Sigaroodi R. Rahimi M.H. Farzaei M. Hodjat M. Baeeri M. Rahimifard M. Navaei-nigjeh M. Abdollahi R. Hajiaghaee*
Abstract	Background and objectives: Luteolin (3′,4′,5,7-tetrahydroxy flavone) is one of the most common flavones, which is naturally found in several edible plants and traditional medicine. It is known as a non-toxic compound with anti-inflammatory, antinociceptive, anticarcinogenic, antimutagenic, and antiangiogenic properties. Luteolin has antiproliferative activity against different human hormone dependent cancer cells e.g. breast, prostate, and thyroid. Due to its bacteriostatic properties and strong antioxidant potential, luteolin is valuable in the management of diverse diseases including peptic ulcers. There are some evidences on wound healing effect of luteolin on diabetic rats and in this work, an in vitro model of wound healing was used to study the wound healing effect of luteolin. Methods: Different concentrations of luteolin were applied in MTT and scratch assay on 3T3 fibroblast cells. FBS-free medium was used as the negative control. Cell proliferation and migration during scratch contraction was calculated. Annexin V and cell cycle analyses were performed to study the effect of luteolin on cell proliferation. Result: The results showed that, scratch contraction was observed significantly (p
Related Links	http://www.rjpharmacognosy.ir/article_52984_a7beaebb755e1c621abf73f19d6c5cef.pdf
ISSN	23454458
e-ISSN	23455977
Journal	Research Journal of Pharmacognosy
Issue Number	Supplement
Volume Number	4
Language	English
Publisher	Iranian Society of Pharmacognosy
Publisher Place	Iran
Access Restriction	Open
Subject Keyword	Pharmacy and Materia Medica Luteoline Scratch Assay Wound Healing
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Complementary and Alternative Medicine

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