NDLI: β-Arrestin1 Promotes Colorectal Cancer Metastasis Through GSK-3β/β-Catenin Signaling- Mediated Epithelial-to-Mesenchymal Transition

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Qing Song Zhifen Han Xinnan Wu Yan Wang Lihong Zhou Liu Yang Ningning Liu Hua Sui Jianfeng Cai Qing Ji Qi Li
Abstract	Recurrence and metastasis seriously affects the prognosis of patients with tumors, and the epithelial-to-mesenchymal transition (EMT) plays a key role in promoting tumor invasion and metastasis. Previous studies have showed that β-arrestin1 acted as a tumor-promoting factor in multiple types of tumor. However, the exact role and mechanism of β-arrestin1 in colorectal cancer (CRC) progression remains to be elucidated. Our research aimed to explore the potential mechanism underlying the role of β-arrestin1 in CRC metastasis. The expression of β-arrestin1 was investigated in both primary and metastatic CRC tissues using the GSE41258 database, and it was revealed that CRC patients with liver/lung metastasis had a higher expression level of β-arrestin1, and the expression level of β-arrestin1 was inversely correlated with the prognosis of CRC patients. Further in vitro mechanism studies indicated that β-arrestin1 had the ability to promote the migration of CRC cells through regulating the EMT process by activating Wingless/integration-1 (Wnt)/β-catenin signaling pathways. Blocking Wnt/β-catenin signaling with inhibitor ICG001 decreased the promoting effect of β-arrestin1 on EMT in CRC. In vivo imaging experiments further demonstrated the promoting effect of β-arrestin1 on the lung metastasis of CRC cells by tail vein injection in mice. The results of this paper suggest that β-arrestin1 promotes EMT via Wnt/β-catenin signaling pathway in CRC metastasis, and provides a novel therapeutic target for CRC metastasis.
e-ISSN	2296634X
DOI	10.3389/fcell.2021.650067
Journal	Frontiers in Cell and Developmental Biology
Volume Number	9
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2021-01-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Biology (general) Epithelial-to-mesenchymal Transition Colorectal Cancer Metastasis Β-arrestin1 Wnt/β-catenin Signaling Pathway
Content Type	Text
Resource Type	Article

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