Enhanced /3-adrenergic receptors in the brain and pancreas during pancreatic regeneration in weanling rats

Content Provider	CUSAT-Thesis
Author	Ani Das, V. Remya, Robinson Paulose, C. S.
Abstract	Adrenergic stimulation has an inyortant role in the pancreatic It-cell proliferation and insulin secretion. In the present study. wehave investigaled how sympathetic system mgulales the panrrealic n I rnerui nr ht an:ilyiing I'pinephi inn 1111 ), Norepinephrinc(NE) and /1-adrenergic receptor changes in the brain as (%eli is in the I swirls. Fill and NII showed a significant decrease inthe brain regions, pancreas and plasma :rt 72Ius iller partial prurcrealectonty. We observed an increase in the circulating insulinlevels at 72 hrs. Scatchard analysis using I CHI propranolol showed a significant increase in the number of loth the low affinityand high affinity t-adrenergic receplors in cerebral cortex and hypothalamus of partially pancreatectornised rats during peakDNA synthesis. The affinity of the receptors decrea,ed significantly in the low and high affinity receptors of cerebral cortexand the high affinity hypothalamic receptors. In file brain stein, low affinity receptors were increased significantly duringregeneration whereas there was no change in the high affinity receptors. The pancreatic ff-adrenergic receptors were also upregulated at 72 firs after partial panerealectony. In vitro studies showed that /i-adrenergic receptors are positive regulators ofislet cell proliferation and insulin secretion. Thus our results suggest that the t-adrenergic receptors are functionally enhancedduring pancreatic regeneration, which in turn increases pancreatic ft-cell proliferation an(hilisulin secretion in wean hug rats.
File Format	PDF
Language	English
Publisher	Department of Bio Technology
Access Restriction	Open
Subject Keyword	pancreatic regeneration epinephrine norepinephrine f(-adrenergic receptors, propanolol
Content Type	Text
Resource Type	Article