NDLI: Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats

Content Provider	CUSAT-Thesis
Author	Mohanan, Valiyaveettil Finla, Chathu Paulose, Cheramadathikudyil S.
Abstract	The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regenerationusing 60-70% pancreatectomy. The 5-HT and 5-HT2c receptor kinetics were studied in cerebral cortex and brain stem of shamoperated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [3H] mesulergine in cerebralcortex showed a significant decrease (p < 0.05) in maximal binding (B^,ax) without any change in Kd in 72 h pancreatectomisedrats compared with sham. The decreased Bmax reversed to sham level by 7 days after pancreatectomy. In brain stem , Scatchardanalysis showed a significant decrease (p < 0.01) in Bax with a significant increase (p < 0.01) in Kd. Competition analysisin brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days afterpancreatectomy. Thus the results suggest that 5-HT through the 5-HT2C receptor in the brain has a functional regulatory role inthe pancreatic regeneration. (Mol Cell Biochem 272: 165-170, 2005)
File Format	PDF
Language	English
Publisher	Department of Bio Technology
Access Restriction	Open
Subject Keyword	cerebral cortex brain stem 5-HT2C receptor pancreas regeneration
Content Type	Text
Resource Type	Article

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