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Meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapy
| Content Provider | CSIR - National Institute for Interdisciplinary Science and Technology (NIIScT) |
|---|---|
| Author | Thomas, Ajesh P. Babu, P. S. Saneesh Nair, S. Asha Ramakrishnan, S. Ramaiah, D. Chandrashekar, T. K. Srinivasan, A. Pillai, M. Radhakrishna |
| Abstract | A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS)generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques |
| Starting Page | 5110 |
| Ending Page | 5120 |
| Page Count | 10 |
| Journal | Journal of Medicinal Chemistry |
| Volume Number | 55 |
| Issue Number | 11 |
| Language | English |
| Publisher | American Chemical Society |
| Publisher Date | 2012-06-14 |
| Access Restriction | Authorized |
| Subject Keyword | N-confused porphyrin Photodynamic therapy Photosensitizer Singlet oxygen generation Core-modified porphyrins Photophysical properties Induced apoptosis |
| Content Type | Text |
| Resource Type | Article |