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β-Cyclodextrin as a photosensitizer carrier: Effect on photophysical properties and chemical reactivity of squaraine dyes
| Content Provider | CSIR - National Institute for Interdisciplinary Science and Technology (NIIScT) |
|---|---|
| Author | Arun, K. T. Dhanya, T. J. Rekha, R. A. Ramaiah, D. |
| Abstract | With the objective of understanding the utility of beta-cyclodextrin (beta-CD) as a carrier system, we have investigated its interactions with a few near-infrared absorbing squaraine dyes (i.e., 1a,b and 2a,b) through absorption and steady-state and time-resolved fluorescence techniques. The addition of beta-CD to the phloroglucinol dyes la,b resulted in a significant bathochromic shift in absorption, together with a ca. 1.5-2.5-fold enhancement in fluorescence intensity, whereas for the aniline-based dyes 2a,b, a hypsochromic shift in the absorption and a ca. 5-12-fold fluorescence enhancement were observed in a 10% (v/v) ethanol/water mixture. Benesi-Hildebrand analysis showed that both the dyes 1 a,b and 2a,b form 2:1 stoichiometric complexes with beta-CD. The complex formation was confirmed by competitive binding analysis employing adamantyl-1-carboxylic acid (ACA) and adamantyl-1-ammonium chloride (ADAC). The displacement of the dyes la,b and 2a,b from the [dye-beta-CD] complex by ADAC and ACA unambiguously establishes the encapsulation of these dyes in the hydrophobic nanocavity of beta-CD. Uniquely, the formation of the inclusion complexes with beta-CD provides unusual protection from nucleophilic attack by aminothiols such as cysteine and glutathione for dyes 1a,b, whereas negligible protection was observed for dyes 2a,b. These results demonstrate the substituent-dependent encapsulation of potentially useful squaraine dyes in beta-CD, thereby indicating its potential as a carrier system for the squaraine dyes 1a,b useful in photodynamic therapy. |
| Starting Page | 7122 |
| Ending Page | 7128 |
| Page Count | 6 |
| ISSN | 15206106 |
| Journal | Journal of Physical Chemistry B |
| Volume Number | 115 |
| Issue Number | 21 |
| Language | English |
| Publisher | American Chemical Society |
| Publisher Date | 2011-06-02 |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Organic solar-cells Near-ir dyes Fluorescence emission Xerographic properties Photodynamic therapy Squarylium dyes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry Surfaces, Coatings and Films Materials Chemistry Medicine |
