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Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats.
| Content Provider | CSIR - Central Food Technological Research Institute (CFTRI) |
|---|---|
| Author | Srinivasan, K. Radhakrishnamurthy, R. |
| Abstract | PESTAB. Weanling male rats were maintained for 14-18 days on diets containing no pesticide (controls) or 800 ppm of beta-BHC or gamma-BHC. The animals were observed for 2 weeks and sacrificed during the third week. Protein and the activities of alanine and asparatate 2-oxoglutarate aminotransferase, alkaline and acid phosphatase, glucose-6-phosphatase, and glucose-6-phosphate dehydrogenase in the liver and kidney tissues were determined. During the third week, beta-BHC produced signs of severe toxicity culminating in coma and death; it produced no growth retardation. gamma-BHC produced loss of apetite and growth retardation during the first week only. beta-BHC produced significant increases in hepatic alanine aminotransferase (80%), the renal alkaline and acid phosphatase (125% and 35%, respectively), and hepatic glucose-6-phosphate dehydrogenase (130%), and significant decreases in hepatic aspartate aminotransferase (30%), renal alanine aminotransferase (35%), the hepatic alkaline and acid phosphatases (45% and 40%, respectively), and hepatic glucose-6-phosphatase (30%). gamma-BHC produced significant increase in hepatic alanine aminotransferase (50%), renal acid phosphate dehydrogenase (40%), and significant decreases in hepatic aspartate aminotransferase (30%) and the hepatic alkaline and acid phosphatases (35% each). |
| Starting Page | 598 |
| Ending Page | 600 |
| Page Count | 3 |
| File Format | |
| Journal | Current Science. |
| Volume Number | 46 |
| Language | English |
| Access Restriction | Authorized |
| Subject Keyword | Enzyme Biochemistry Toxicology |
| Content Type | Text |
| Resource Type | Article |
