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The influence of droplet size on the stability, in vivo digestion, and oral bioavailability of vitamin E emulsions
| Content Provider | CSIR - Central Food Technological Research Institute (CFTRI) |
|---|---|
| Author | Muthukumar, S. P. Parthasarathi, S. Anandharamakrishnan, C. |
| Date of Submission | 2016-01-01 |
| Abstract | Arginine plays an important role in cardiovascular diseases, especially as a nitric oxide precursor leading tovasodilation. The present study focuses, on the effect of the arginine/lysine (Arg : Lys) ratio in the protein form and free amino acid form on hypertension in hypercholesterolemic Wistar rats. Hypertension was induced by administration of L-NAME (Nu-nitro-L-arginine methyl ester hydrochloride) orally for 16 weeks in high cholesterol fed Wistar rats. Arginine : lysine ratio is high in Moringa seed protein isolate(MPI) compared to other oilseed proteins. After inducting, the treatment groups were supplemented withdiets containing Moringa seed protein isolate (MPI-LN) and free amino acids (FAA-LN) for 6 weeks. A decrease in systolic blood pressure (SBP) was observed after treatment. The MPI-LN and FAA-LN exhibited 126.6 ± 2.2 mm Hg and 127.5 ± 0.2 mm Hg of SBP respectively, which is less compared to thehypertensive rats (146.7 ± 4.5 mm Hg). The hypertensive markers such as angiotensin-I converting enzyme (ACE) and nitrate levels in kidney were analysed. The MPI-LN and FAA-LN exhibited 10.30 ± 3.7 nmoles per mg per min and 37.56 ± 3.7 nmoles per mg per min ACE activity respectively. In both treatment groups, a 50% decrease in ACE activity was observed compared to hypertensive rats. Increase(30%) in nitrate levels was observed in MPI-LN (0.47 ± 0.04 mM g^-1) and FAA-LN (0.4 ± 0.06 mM g^-1)compared to hypertensive rats. From the results, it is evident that Arg : Lys has a role in hypertension regulation. Lipid profiles of blood plasma showed a decrease in plasma triacylglyceride and livertriacyglyceride levels in the treatment groups. The Arg : Lys ratio in both the protein form (MPI) and free amino acid form strongly affects the metabolic pathways of hypertension with moderate effect on hypercholesterolemia. |
| Starting Page | 2294 |
| Ending Page | 2302 |
| Page Count | 9 |
| File Format | |
| ISSN | 20426496 2042650X |
| Volume Number | 7 |
| Alternate Webpage(s) | http://ir.cftri.com/13344/ |
| Journal | Food and Function |
| Language | English |
| Access Restriction | Limited |
| Subject Keyword | Invivo Nanoemulsion Vitamins |
| Content Type | Text |
| Resource Type | Article |
| Subject | Food Science Medicine |
