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Aldosterone Assays: An Urgent Need for Improvement
| Content Provider | CiteSeerX |
|---|---|
| Abstract | It should not be forgotten that the concentration of aldosterone in plasma is only 1 thousandth that of cortisol. In this issue of Clinical Chemistry, Schirpenbach et al. (1) draw much-needed attention to current problems with measurement of aldosterone. The issue is extremely important in clinical practice after recognition that pri-mary aldosteronism is a much more common cause of hypertension than previously thought (2–6). Conse-quently, we have seen a marked increase in screening for this disorder by measuring the ratio of aldosterone to renin (ARR) and by suppression testing to definitively confirm or exclude the diagnosis, both tests that critically depend on reliable aldosterone measurement. Because every hypertensive patient deserves testing to reliably diagnose or exclude this specifically treatable and some- |
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| Content Type | Text |