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Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. Drug Metab Dispos
| Content Provider | CiteSeerX |
|---|---|
| Author | Fukano, Y. Kawazu, K. |
| Abstract | The disposition and metabolism of tafluprost, an ester prodrug of the 15,15-difluoro-prostaglandin F2 antiglaucoma agent, have been studied in rats after ocular administration. Radioactivity was absorbed very rapidly into the eye and systemic circulation after a single ocular dose of 0.005 % [3H]tafluprost ophthalmic solution, with maximum levels in plasma and most eye tissues occurring within 15 min. The absorption ratio of radioactivity was approxi-mately 75%, suggesting the high availability of ocular administra-tion of tafluprost. Approximately 10 % of the dose was present in cornea at this time, and radioactivity concentrations in this tissue exceeded those in aqueous humor and iris/ciliary body throughout the 24-h study period. After repeated daily ocular doses, radioac-tivity levels remained greatest in cornea, followed by iris/ciliary body that replaced aqueous humor as the eye tissue containing the second highest radioactivity concentration. In female rats, radio- |
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| Access Restriction | Open |
| Content Type | Text |