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Activation of Presynaptic 5-Hydroxytryptamine-Like Receptors on Glutamatergic Terminals Inhibits N-Methyl-D-Aspartate- Induced Cyclic GMP Production in Rat Cerebellar Slices1 (1991)
| Content Provider | CiteSeerX |
|---|---|
| Author | Barzizza, Alessandra Raiteri, Maurizio Maura, Guido |
| Abstract | In rat cerebellar slices, depolarization with 35 mM KCI caused increase of cyclic GMP (cGMP) production. This increase was Ca-dependent, similar to the K-evoked release of glutamate and aspartate in the same preparation. The K-induced CGMP formation was inhibited in a concentration-dependent manner by D-(-)-2-amino-5-phosphonopentanoic acid (maximal inhibition 60-70%; lC = 0.01 9 tiM) indicating the involvement of N-methyl-D-aspartate receptors probably activated by excitatory amino acids (EAA5) released by K-depolarization. The CGMP production evoked by high-K was also potently inhibited by 5-hydroxytryptamine (5-HT; lCse 0.42 nM) or by 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT; ICse 1 nM). Methiothepin prevented the action of both 5-HT and 8-OH-DPAT. These data suggest the involvement of 5-HT1-Iike receptors. When added |
| File Format | |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Content Type | Text |
