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Comparison of Tumor-Specific Simian Virus 40-lnduced Transplantation Antigens 1. 2 Mouse and Hamster
| Content Provider | CiteSeerX |
|---|---|
| Author | Coggin, Joseph H. |
| Abstract | ABSTRACT-The tumor-specific transplantation antigen (TST A), which appears on papovavirus-Induced sarcomas of the hamster, has been demonstrated to be common In any cell type trans-formed by a given virus. Other studies have suggested that cell-free TST A has been successfully Isolated from mouse sarcoma cells Induced In vitro by simian virus 40 (SV40). Considerable work has been done toward purifying and Identifying this mouse TSTA. We obtained preparations from the laboratory reporting the Isolation of TSTA from the SV40-lnduced mouse sarcoma cells as well as cell lines from which the preparations of TST A had been derived. These extracts, as well as fresh extracts made from the appropriate SV40-lnduced mouse tumor line, were tested for their ability to Interrupt tumor production In mice after challenge with homologous and heterologous sarcomas and to prevent SV40 primary tumor Induction In hamsters. The findings |
| File Format | |
| Access Restriction | Open |
| Content Type | Text |
