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Modulation of Relaxant Responses Evoked By a Nitric Oxide Donor and By Nonadrenergic, Noncholinergic Stimulation By Isozyme-Selective Phosphodiesterase Inhibitors in Guinea Pig (1994)
| Content Provider | CiteSeerX |
|---|---|
| Author | Ews, James L. Conanan, Norlando D. |
| Abstract | Nonadrenergic, noncholinergic relaxations were elicited by field stimulation (1-1 6 Hz, I msec, 8 V for 1 5 sec) of guinea pig trachea desensitized with capsalcin (3 pM), pretreated with atropine (1 M), propranolol (1 MM), indomethacin (3 M) and treated with a-chymotrypsin (2 U/mI) and contracted with 3 p.M histamine. The effect of the phosphodiesterase (PDE) isozyme selective inhibitors siguazodan (PDE Ill-selective), rolipram (PDE IV-selective), denbufylline (PDE IV-selective) and zapn-neat (POE V-selective) was examined on the relaxant responses to field stimulation and on relaxations elicited by the nitric oxide donor 3-morphollnosydnonlmine-N-ethylcarbamide (SIN-i). The response to field stimulation in the presence of a-chymot-rypsin (the putative nitric oxide component), at all the frequen-cies tested, was potentiated significantly by the PDE IV inhibi- |
| File Format | |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Content Type | Text |
