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PREFRONTAL CORTEX LTP AND BEHAVIOURAL SENSITIZATION DOPAMINERGIC MODULATION OF GLUTAMATE-BASED LONG-TERM POTENTIATION IN THE MEDIAL PREFRONTAL CORTEX AND THE MAINTENANCE OF BEHAVIOURAL SENSITIZATION, IN VIVO By
| Content Provider | CiteSeerX |
|---|---|
| Author | Coppa-Hopman, Romina D. Se, Hon B. |
| Abstract | ii Orug addiction and behavioural sensitization are associated with reorganization of mesolimbocortical circuitry, which we have attempted to model with glutamatergic-based long-term potentiation (L TP) in the medial prefrontal cortex (mPFC). The objective of the experiments was to examine the effects of dopamine-1 (01) and dopamine-2 (02) receptor family specific agonists and antagonists on L TP in the mPFC in the chronic in vivo preparation using fully-awake, freely-moving rats. Male Long-Evans rats were surgically implanted with stimulating electrodes into the corpus callosum and recording electrodes into the mPFC. Subjects were systemically administered a drug together with high frequency stimulation for the induction of L TP. The rats treated with the 0 1 receptor agonist A68930 (OAmg/kg/ml) showed L TP levels equal to those in the saline L TP group. The 0 1 receptor antagonist SKF83566 (0. 15m~,/kg/ml) blocked the expression of L TP, and instead induced significant long-term depression. |
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