NDLI: The Effect of Silk Fibroin/Nano-hydroxyapatite/Corn Starch Composite Porous Scaffold on Bone Regeneration in the Rabbit Calvarial Defect Model (2011)

Content Provider	CiteSeerX
Author	Korean, J. Park, Yong-Tae Kwon, Kwang-Jun Park, Young-Wook Kim, Seong-Gon Kim, Chan-Woo Jo, You-Young Kweon, Hae-Yong Kang, Seok-Woo
Abstract	Purpose: This study evaluated the capability of bone formation with silk fibroin/nano-hydroxyapatite/corn starch composite scaffold as a bone defect replacement matrix when grafted in a calvarial bone defect of rabbits in vivo. Methods: Ten New Zealand white rabbits were used for this study and bilateral round-shaped defects were formed in the parietal bone (diameter: 8.0 mm). The silk fibroin 10 % nano-hydroxyapatite/30 % corn starch/60 % composite scaffold was grafted into the right parietal bone (experimental group). The left side (control group) was grafted with a nano-hydroxyapatite (30%)/corn starch (70%) scaffold. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (μCT) of each specimen was taken. Subsequently, the specimens were decalcified and stained with Masson's trichrome for histological and histomorphometric analysis. Results: The average μCT and histomorphometric measures of bone formation were higher in the control group than in
File Format	PDF
Publisher Date	2011-01-01
Access Restriction	Open
Content Type	Text

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