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Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice
| Content Provider | CiteSeerX |
|---|---|
| Author | Lanz, Bernard Poitry-Yamate, Carole Gruetter, Rolf |
| Abstract | Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. Methods: In the present study, we took advantage of the high spa-tial resolution of a recent dedicated small-animal scanner to extract the input function from the 18F-FDG PET images in Sprague–Dawley rats (n5 4) and C57BL/6 mice (n5 5), using the vena cava. In the rat experiments, the validation of the image-derived input function (IDIF) method was made using an external microvolumetric blood counter as reference for the determination of the arterial input func-tion, the measurement of which was confirmed by additional man-ually obtained blood samples. Correction for tracer bolus dispersion in blood between the vena cava and the arterial tree was applied. In addition, simulation studies were undertaken to probe the impact of the different IDIF extraction approaches on the determined cerebral |
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