NDLI: Magnesium Intake and Risk of Type 2 Diabetes Meta-analysis of prospective cohort studies

Content Provider	CiteSeerX
Author	Bsc, Jia-Yi Dong Qin, Li-Qiang
Abstract	OBJECTIVE—Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence.We aimed to examine the association betweenmagnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. RESEARCH DESIGN AND METHODS—We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates. RESULTS—Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95 % CI 0.73–0.84]). This association was not sub-stantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI $25 kg/m2) but not in normal-weight individuals (BMI,25 kg/m2), although test for interaction was not statistically significant (Pinteraction = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95 % CI 0.82–0.89). Sensitivity
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