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Identification of Nedd4 E3 Ubiquitin Ligase as a Binding Partner and Regulator of MAK-V Protein Kinase (2012)
| Content Provider | CiteSeerX |
|---|---|
| Author | Kalinichenko, Svetlana V. Itoh, Keiji Korobko, Elena V. Sokol, Sergei Y. Buchman, Vladimir L. Korobko, Igor V. |
| Abstract | MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its activity remain largely unknown. We identified Nedd4 as an interaction partner for MAK-V protein kinase. However, this HECT-type E3 ubiquitin ligase is not involved in the control of MAK-V degradation by the ubiquitin-proteasome system that regulates MAK-V abundance in cells. However, Nedd4 in an ubiquitin ligase-independent manner rescued developmental defects in Xenopus embryos induced by MAK-V over-expression, suggesting physiological relevance of interaction between MAK-V and Nedd4. This identifies Nedd4 as the first known regulator of MAK-V function. |
| File Format | |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Content Type | Text |
