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Delivery of the Cu/Znsuperoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology 120 (2001)
| Content Provider | CiteSeerX |
|---|---|
| Author | Wheeler, Michael D. Kono, Hiroshi Yin, Ming Rusyn, Ivan Froh, Matthias Connor, Henry D. Mason, Ronald P. Samulski, R. J. Thurman, Ronald G. |
| Abstract | ciated with an increase in oxidants from a variety of possible sources. Therefore, it was hypothesized that increased and stable expression of the antioxidant en-zyme Cu/Zn–superoxide dismutase (SOD1) would dimin-ish oxygen free radicals and reduce alcohol-induced liver injury. Methods: To test this hypothesis, rats were given recombinant adenovirus containing Cu/Zn–superoxide dismutase (Ad.SOD1) or -galactosidase (Ad.lacZ) and fed ethanol enterally for 3 weeks. Results: SOD was increased significantly 3–5-fold over endogenous levels in both hepatocytes as well as Kupffer cells 3 weeks after infection. Serum transaminase levels and pathol-ogy were elevated significantly in Ad.lacZ-treated ani-mals by using an intragastric feeding model. This effect was blunted significantly in Ad.SOD1-infected animals. |
| File Format | |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Content Type | Text |